Nature Communications (Jul 2020)

Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution

  • Yinghua Li,
  • Bo Li,
  • Wei Li,
  • Yuan Wang,
  • Seçkin Akgül,
  • Daniel M. Treisman,
  • Kevin A. Heist,
  • Brianna R. Pierce,
  • Benjamin Hoff,
  • Cheng-Ying Ho,
  • David O. Ferguson,
  • Alnawaz Rehemtulla,
  • Siyuan Zheng,
  • Brian D. Ross,
  • Jun Z. Li,
  • Yuan Zhu

DOI
https://doi.org/10.1038/s41467-020-17382-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 19

Abstract

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Recent studies suggest spatial segregation of tumor initiation and manifestation in IDH-WT glioblastomas. Here, the authors use serial MRI/3D-reconstruction, whole-genome sequencing and spectral karyotyping-based single-cell phylogenetic tree building to establish this unique evolutionary mode in a murine model.