A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Hae-Eun H. Park; Wooseon Hwang; Seokjin Ham; Eunah Kim; Ozlem Altintas; Sangsoon Park; Heehwa G. Son; Yujin Lee; Dongyeop Lee; Won Do Heo; Seung-Jae V. Lee

doi:10.1038/s41467-021-25920-w

Nature Communications (Sep 2021)

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Hae-Eun H. Park,
Wooseon Hwang,
Seokjin Ham,
Eunah Kim,
Ozlem Altintas,
Sangsoon Park,
Heehwa G. Son,
Yujin Lee,
Dongyeop Lee,
Won Do Heo,
Seung-Jae V. Lee

Affiliations

Hae-Eun H. Park: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Wooseon Hwang: Department of Life Sciences, Pohang University of Science and Technology
Seokjin Ham: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Eunah Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Ozlem Altintas: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology
Sangsoon Park: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Heehwa G. Son: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Yujin Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Dongyeop Lee: Department of Life Sciences, Pohang University of Science and Technology
Won Do Heo: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Seung-Jae V. Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-021-25920-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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