Nature Communications (May 2021)
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
- Raha Pazoki,
- Marijana Vujkovic,
- Joshua Elliott,
- Evangelos Evangelou,
- Dipender Gill,
- Mohsen Ghanbari,
- Peter J. van der Most,
- Rui Climaco Pinto,
- Matthias Wielscher,
- Matthias Farlik,
- Verena Zuber,
- Robert J. de Knegt,
- Harold Snieder,
- André G. Uitterlinden,
- Lifelines Cohort Study,
- Julie A. Lynch,
- Xiyun Jiang,
- Saredo Said,
- David E. Kaplan,
- Kyung Min Lee,
- Marina Serper,
- Rotonya M. Carr,
- Philip S. Tsao,
- Stephen R. Atkinson,
- Abbas Dehghan,
- Ioanna Tzoulaki,
- M. Arfan Ikram,
- Karl-Heinz Herzig,
- Marjo-Riitta Järvelin,
- Behrooz Z. Alizadeh,
- Christopher J. O’Donnell,
- Danish Saleheen,
- Benjamin F. Voight,
- Kyong-Mi Chang,
- Mark R. Thursz,
- Paul Elliott,
- the VA Million Veteran Program
Affiliations
- Raha Pazoki
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Marijana Vujkovic
- Corporal Michael J. Crescenz VA Medical Center
- Joshua Elliott
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Evangelos Evangelou
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Dipender Gill
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center Rotterdam
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Rui Climaco Pinto
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Matthias Wielscher
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Matthias Farlik
- Department of Dermatology, Medical University of Vienna
- Verena Zuber
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Robert J. de Knegt
- Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus University Medical Center Rotterdam
- Lifelines Cohort Study
- Julie A. Lynch
- VA Salt Lake City Health Care System
- Xiyun Jiang
- Division of Biomedical Sciences, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London
- Saredo Said
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- David E. Kaplan
- Corporal Michael J. Crescenz VA Medical Center
- Kyung Min Lee
- VA Salt Lake City Health Care System
- Marina Serper
- Corporal Michael J. Crescenz VA Medical Center
- Rotonya M. Carr
- Corporal Michael J. Crescenz VA Medical Center
- Philip S. Tsao
- VA Palo Alto Health Care System
- Stephen R. Atkinson
- Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London
- Abbas Dehghan
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Ioanna Tzoulaki
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- M. Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center Rotterdam
- Karl-Heinz Herzig
- Institute of Biomedicine, Medical Research Center Oulu, Oulu University
- Marjo-Riitta Järvelin
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- Behrooz Z. Alizadeh
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Christopher J. O’Donnell
- VA Boston Healthcare System
- Danish Saleheen
- Departments of Medicine and Cardiology, Columbia University
- Benjamin F. Voight
- Corporal Michael J. Crescenz VA Medical Center
- Kyong-Mi Chang
- Corporal Michael J. Crescenz VA Medical Center
- Mark R. Thursz
- Division of Digestive Diseases, Department of Metabolism, Digestion & Reproduction, Imperial College London
- Paul Elliott
- Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health
- the VA Million Veteran Program
- DOI
- https://doi.org/10.1038/s41467-021-22338-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.
