Nature Communications (Nov 2017)
Comparative genomic analysis of esophageal squamous cell carcinoma between Asian and Caucasian patient populations
- Jiaying Deng,
- Hu Chen,
- Daizhan Zhou,
- Junhua Zhang,
- Yun Chen,
- Qi Liu,
- Dashan Ai,
- Hanting Zhu,
- Li Chu,
- Wenjia Ren,
- Xiaofei Zhang,
- Yi Xia,
- Menghong Sun,
- Huiwen Zhang,
- Jun Li,
- Xinxin Peng,
- Liang Li,
- Leng Han,
- Hui Lin,
- Xiujun Cai,
- Jiaqing Xiang,
- Shufeng Chen,
- Yihua Sun,
- Yawei Zhang,
- Jie Zhang,
- Haiquan Chen,
- Shijian Zhang,
- Yi Zhao,
- Yun Liu,
- Han Liang,
- Kuaile Zhao
Affiliations
- Jiaying Deng
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Hu Chen
- Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine
- Daizhan Zhou
- Department of General Surgery, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine
- Junhua Zhang
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Yun Chen
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Qi Liu
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Dashan Ai
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Hanting Zhu
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Li Chu
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Wenjia Ren
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Xiaofei Zhang
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Yi Xia
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- Menghong Sun
- Department of Oncology, Shanghai Medical College, Fudan University
- Huiwen Zhang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School
- Jun Li
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Xinxin Peng
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Liang Li
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Leng Han
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School
- Hui Lin
- Department of General Surgery, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine
- Xiujun Cai
- Department of General Surgery, Sir Run Run Shaw Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine
- Jiaqing Xiang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Shufeng Chen
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Yihua Sun
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Yawei Zhang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Jie Zhang
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Haiquan Chen
- Department of Thoracic Surgery, Fudan University Shanghai Cancer Center
- Shijian Zhang
- Precision Scientific (Beijing) Co., Ltd
- Yi Zhao
- Precision Scientific (Beijing) Co., Ltd
- Yun Liu
- Institute of Biomedical Sciences, Fudan University
- Han Liang
- Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine
- Kuaile Zhao
- Department of Radiation Oncology, Fudan University Shanghai Cancer Center
- DOI
- https://doi.org/10.1038/s41467-017-01730-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Esophageal squamous cell carcinoma (ESCC) exhibits differences in incidence and survival patterns among races. Here, analysis of Chinese and TCGA ESCC patients reveals that Asian patients exhibit higher TP53, EP300 and NFE2L2 mutational frequencies, and mutated CSMD3 associates with better prognosis.
