Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

Na Zhao; Reid T. Powell; Xueying Yuan; Goeun Bae; Kevin P. Roarty; Fabio Stossi; Martina Strempfl; Michael J. Toneff; Hannah L. Johnson; Sendurai A. Mani; Philip Jones; Clifford C. Stephan; Jeffrey M. Rosen

doi:10.1038/s41467-021-24545-3

Nature Communications (Jul 2021)

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

Na Zhao,
Reid T. Powell,
Xueying Yuan,
Goeun Bae,
Kevin P. Roarty,
Fabio Stossi,
Martina Strempfl,
Michael J. Toneff,
Hannah L. Johnson,
Sendurai A. Mani,
Philip Jones,
Clifford C. Stephan,
Jeffrey M. Rosen

Affiliations

Na Zhao: Department of Molecular and Cellular Biology, Baylor College of Medicine
Reid T. Powell: Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology
Xueying Yuan: Department of Molecular and Cellular Biology, Baylor College of Medicine
Goeun Bae: Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology
Kevin P. Roarty: Department of Molecular and Cellular Biology, Baylor College of Medicine
Fabio Stossi: Department of Molecular and Cellular Biology, Baylor College of Medicine
Martina Strempfl: Graz University of Technology, NAWI Graz
Michael J. Toneff: Department of Biology, Widener University
Hannah L. Johnson: Integrated Microscopy Core, Baylor College of Medicine
Sendurai A. Mani: Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center
Philip Jones: Institute of Applied Cancer Science (IACS), University of Texas MD Anderson Cancer Center
Clifford C. Stephan: Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology
Jeffrey M. Rosen: Department of Molecular and Cellular Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-021-24545-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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