Nature Communications (Mar 2022)

Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling

Kelly J. Culhane,
Tejas M. Gupte,
Indrani Madhugiri,
Chetan J. Gadgil,
Sivaraj Sivaramakrishnan

Affiliations

Kelly J. Culhane: Department of Genetics, Cell Biology and Development, University of Minnesota
Tejas M. Gupte: Department of Genetics, Cell Biology and Development, University of Minnesota
Indrani Madhugiri: Chemical Engineering Division, CSIR-National Chemical Laboratory
Chetan J. Gadgil: Chemical Engineering Division, CSIR-National Chemical Laboratory
Sivaraj Sivaramakrishnan: Department of Genetics, Cell Biology and Development, University of Minnesota

DOI: https://doi.org/10.1038/s41467-022-28789-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

Experimentally validated kinetic simulations uncover transient enhancement of GPCR ternary complex formation by allokairic effectors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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