USP35 regulates mitotic progression by modulating the stability of Aurora B

Jinyoung Park; Mi-Sun Kwon; Eunice EunKyeong Kim; Hyunsook Lee; Eun Joo Song

doi:10.1038/s41467-018-03107-0

Nature Communications (Feb 2018)

USP35 regulates mitotic progression by modulating the stability of Aurora B

Jinyoung Park,
Mi-Sun Kwon,
Eunice EunKyeong Kim,
Hyunsook Lee,
Eun Joo Song

Affiliations

Jinyoung Park: Molecular Recognition Research Center, Korea Institute of Science and Technology
Mi-Sun Kwon: Department of Biological Sciences & Institute of Molecular Biology and Genetics (IMBG), Seoul National University
Eunice EunKyeong Kim: Biomedical Research Institute, Korea Institute of Science and Technology
Hyunsook Lee: Department of Biological Sciences & Institute of Molecular Biology and Genetics (IMBG), Seoul National University
Eun Joo Song: Molecular Recognition Research Center, Korea Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-018-03107-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

Aurora B kinase is a member of the chromosomal passenger complex, which is an indispensable regulator of mitosis. Here the authors show that the deubiquitinating enzyme USP35 has a role in mitotic progression by inhibiting proteasomal degradation of Aurora B kinase, leading to its activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal