Nature Communications (Dec 2019)
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities
- Eugenia Migliavacca,
- Stacey K. H. Tay,
- Harnish P. Patel,
- Tanja Sonntag,
- Gabriele Civiletto,
- Craig McFarlane,
- Terence Forrester,
- Sheila J. Barton,
- Melvin K. Leow,
- Elie Antoun,
- Aline Charpagne,
- Yap Seng Chong,
- Patrick Descombes,
- Lei Feng,
- Patrice Francis-Emmanuel,
- Emma S. Garratt,
- Maria Pilar Giner,
- Curtis O. Green,
- Sonia Karaz,
- Narasimhan Kothandaraman,
- Julien Marquis,
- Sylviane Metairon,
- Sofia Moco,
- Gail Nelson,
- Sherry Ngo,
- Tony Pleasants,
- Frederic Raymond,
- Avan A. Sayer,
- Chu Ming Sim,
- Jo Slater-Jefferies,
- Holly E. Syddall,
- Pei Fang Tan,
- Philip Titcombe,
- Candida Vaz,
- Leo D. Westbury,
- Gerard Wong,
- Wu Yonghui,
- Cyrus Cooper,
- Allan Sheppard,
- Keith M. Godfrey,
- Karen A. Lillycrop,
- Neerja Karnani,
- Jerome N. Feige
Affiliations
- Eugenia Migliavacca
- Nestle Research, EPFL Innovation Park
- Stacey K. H. Tay
- KTP-National University Children’s Medical Institute, National University Hospital
- Harnish P. Patel
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Tanja Sonntag
- Nestle Research, EPFL Innovation Park
- Gabriele Civiletto
- Nestle Research, EPFL Innovation Park
- Craig McFarlane
- Department of Molecular & Cell Biology, College of Public Health, Medical & Veterinary Sciences, James Cook University
- Terence Forrester
- UWI Solutions for Developing Countries, UWI SODECO, University of West Indies
- Sheila J. Barton
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Melvin K. Leow
- Singapore Institute for Clinical Sciences (A*STAR)
- Elie Antoun
- Institute of Developmental Sciences, University of Southampton
- Aline Charpagne
- Nestle Research, EPFL Innovation Park
- Yap Seng Chong
- Singapore Institute for Clinical Sciences (A*STAR)
- Patrick Descombes
- Nestle Research, EPFL Innovation Park
- Lei Feng
- Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore
- Patrice Francis-Emmanuel
- UWI Solutions for Developing Countries, UWI SODECO, University of West Indies
- Emma S. Garratt
- National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust
- Maria Pilar Giner
- Nestle Research, EPFL Innovation Park
- Curtis O. Green
- UWI Solutions for Developing Countries, UWI SODECO, University of West Indies
- Sonia Karaz
- Nestle Research, EPFL Innovation Park
- Narasimhan Kothandaraman
- Singapore Institute for Clinical Sciences (A*STAR)
- Julien Marquis
- Nestle Research, EPFL Innovation Park
- Sylviane Metairon
- Nestle Research, EPFL Innovation Park
- Sofia Moco
- Nestle Research, EPFL Innovation Park
- Gail Nelson
- UWI Solutions for Developing Countries, UWI SODECO, University of West Indies
- Sherry Ngo
- Liggins Institute, University of Auckland
- Tony Pleasants
- Liggins Institute, University of Auckland
- Frederic Raymond
- Nestle Research, EPFL Innovation Park
- Avan A. Sayer
- Academic Geriatric Medicine, , University of Southampton
- Chu Ming Sim
- Singapore Institute for Clinical Sciences (A*STAR)
- Jo Slater-Jefferies
- Institute of Developmental Sciences, University of Southampton
- Holly E. Syddall
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Pei Fang Tan
- Singapore Institute for Clinical Sciences (A*STAR)
- Philip Titcombe
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Candida Vaz
- Singapore Institute for Clinical Sciences (A*STAR)
- Leo D. Westbury
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Gerard Wong
- Singapore Institute for Clinical Sciences (A*STAR)
- Wu Yonghui
- Singapore Institute for Clinical Sciences (A*STAR)
- Cyrus Cooper
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Allan Sheppard
- Liggins Institute, University of Auckland
- Keith M. Godfrey
- Medical Research Council Lifecourse Epidemiology Unit, University of Southampton
- Karen A. Lillycrop
- National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust
- Neerja Karnani
- Singapore Institute for Clinical Sciences (A*STAR)
- Jerome N. Feige
- Nestle Research, EPFL Innovation Park
- DOI
- https://doi.org/10.1038/s41467-019-13694-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcriptional signatures indicating mitochondrial dysfunction, associated with reduced mitochondria numbers and lower NAD+ levels in older individuals with sarcopenia.
