Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming

Hyosang Kim; Doyoun Kim; Yisul Cho; Kyungdeok Kim; Junyeop Daniel Roh; Yangsik Kim; Esther Yang; Seong Soon Kim; Sunjoo Ahn; Hyun Kim; Hyojin Kang; Yongchul Bae; Eunjoon Kim

doi:10.1038/s41467-022-32748-5

Nature Communications (Aug 2022)

Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming

Hyosang Kim,
Doyoun Kim,
Yisul Cho,
Kyungdeok Kim,
Junyeop Daniel Roh,
Yangsik Kim,
Esther Yang,
Seong Soon Kim,
Sunjoo Ahn,
Hyun Kim,
Hyojin Kang,
Yongchul Bae,
Eunjoon Kim

Affiliations

Hyosang Kim: Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)
Doyoun Kim: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
Yisul Cho: Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
Kyungdeok Kim: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
Junyeop Daniel Roh: Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
Yangsik Kim: Graduate School of Biomedical Engineering, Korea Advanced Institute for Science and Technology (KAIST)
Esther Yang: Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University
Seong Soon Kim: Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT)
Sunjoo Ahn: Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT)
Hyun Kim: Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University
Hyojin Kang: Division of National Supercomputing, Korea Institute of Science and Technology Information
Yongchul Bae: Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University
Eunjoon Kim: Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s41467-022-32748-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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ARID1B is a chromatin remodeler associated with autism spectrum disorders. Here the authors demonstrate that early postnatal serotonin modulation prevents adult stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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