Nature Communications (Dec 2022)
Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases
- Yuya Nishida,
- Sachiko Yanagisawa,
- Rikuri Morita,
- Hideki Shigematsu,
- Kyoko Shinzawa-Itoh,
- Hitomi Yuki,
- Satoshi Ogasawara,
- Ken Shimuta,
- Takashi Iwamoto,
- Chisa Nakabayashi,
- Waka Matsumura,
- Hisakazu Kato,
- Chai Gopalasingam,
- Takemasa Nagao,
- Tasneem Qaqorh,
- Yusuke Takahashi,
- Satoru Yamazaki,
- Katsumasa Kamiya,
- Ryuhei Harada,
- Nobuhiro Mizuno,
- Hideyuki Takahashi,
- Yukihiro Akeda,
- Makoto Ohnishi,
- Yoshikazu Ishii,
- Takashi Kumasaka,
- Takeshi Murata,
- Kazumasa Muramoto,
- Takehiko Tosha,
- Yoshitsugu Shiro,
- Teruki Honma,
- Yasuteru Shigeta,
- Minoru Kubo,
- Seiji Takashima,
- Yasunori Shintani
Affiliations
- Yuya Nishida
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- Sachiko Yanagisawa
- Graduate School of Science, University of Hyogo
- Rikuri Morita
- Center for Computational Sciences, University of Tsukuba
- Hideki Shigematsu
- RIKEN SPring-8 Center
- Kyoko Shinzawa-Itoh
- Graduate School of Science, University of Hyogo
- Hitomi Yuki
- RIKEN Center for Biosystems Dynamics Research
- Satoshi Ogasawara
- Department of Chemistry, Graduate School of Science, Chiba University
- Ken Shimuta
- Department of Bacteriology I, National Institute of Infectious Diseases
- Takashi Iwamoto
- Department of Medical Biochemistry, Osaka University Graduate School of Frontier Biological Science
- Chisa Nakabayashi
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- Waka Matsumura
- Graduate School of Science, University of Hyogo
- Hisakazu Kato
- Department of Medical Biochemistry, Osaka University Graduate School of Frontier Biological Science
- Chai Gopalasingam
- RIKEN SPring-8 Center
- Takemasa Nagao
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- Tasneem Qaqorh
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- Yusuke Takahashi
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- Satoru Yamazaki
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- Katsumasa Kamiya
- Center for Basic Education Integrated Learning, Kanagawa Institute of Technology
- Ryuhei Harada
- Center for Computational Sciences, University of Tsukuba
- Nobuhiro Mizuno
- Protein Crystal Analysis Division, Japan Synchrotron Radiation Research Institute
- Hideyuki Takahashi
- Department of Bacteriology I, National Institute of Infectious Diseases
- Yukihiro Akeda
- Department of Bacteriology I, National Institute of Infectious Diseases
- Makoto Ohnishi
- Department of Bacteriology I, National Institute of Infectious Diseases
- Yoshikazu Ishii
- Department of Microbiology and Infectious Diseases, Toho University School of Medicine
- Takashi Kumasaka
- Protein Crystal Analysis Division, Japan Synchrotron Radiation Research Institute
- Takeshi Murata
- Department of Chemistry, Graduate School of Science, Chiba University
- Kazumasa Muramoto
- Graduate School of Science, University of Hyogo
- Takehiko Tosha
- RIKEN SPring-8 Center
- Yoshitsugu Shiro
- Graduate School of Science, University of Hyogo
- Teruki Honma
- RIKEN Center for Biosystems Dynamics Research
- Yasuteru Shigeta
- Center for Computational Sciences, University of Tsukuba
- Minoru Kubo
- Graduate School of Science, University of Hyogo
- Seiji Takashima
- Department of Medical Biochemistry, Osaka University Graduate School of Frontier Biological Science
- Yasunori Shintani
- Department of Molecular Pharmacology, National Cerebral and Cardiovascular Center
- DOI
- https://doi.org/10.1038/s41467-022-34771-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Antimicrobial resistance to currently available antibiotics requires innovation of antibiotics. Here, the authors identify a critical inhibitory site in an energy-producing enzyme, which can lead to rational design of antibiotics.
