Clinical Significance of Cytochrome P4502C19 (681G/A) Gene Polymorphism in Residents of the Trans-Baikal Territory in Treatment of Acid-Dependent Diseases

Abstract

Aims. To study the CYP2C19(681A/G) polymorphism among the population of the Trans-Baikal Territory in comparison with data in other regions of Russia and the world. Materials and methods. The study involved 132 people (81 women and 53 men). The median age was 47 (18; 72) years. Genotyping of the 681G/A polymorphic locus of the CYP2C19 gene was performed by polymerase chain reaction. Results. The prevalence of CYP2C19(681G/G) was 105 people (79.6%), CYP2C19(681G/A) — 25 people (18.9%) and CYP2C19(681A/A) — 2 participants (1.5%). Allele A of the CYP2C19 gene in position 681 was found in 14.2%. Allele A is less common in the population of the Trans-Baikal Territory, compared with Asians (China, p <0.001; Japan, p = 0.015) and did not differ in prevalence from Native Americans, Hispanics, African Americans, residents of Moscow, Voronezh, Irkutsk regions and Sakha-Yakutia. CYP2C19(681A/A) was more common in the Asian population than among the Transbaikalians, p = 0.003. The prevalence of the CYP2C19(681A/A) genotype did not differ between the population of the Trans-Baikal Territory, African Americans, Caucasians, and the population of the Moscow and Voronezh regions. Conclusions. The prevalence of the allele A in the population of the Trans-Baikal Territory was 14.2% and was comparable to the Caucasians, but less common than in the Asian population. The prevalence of the CYP2C19(681A/A) was 1.5%, which was consistent with world data among Caucasoid populations and was less common than in Asians.

Keywords

• полиморфизм
• цитохром р450
• аллель
• cyp2c19(681a/g)