Nature Communications (Jul 2020)
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth
- L. M. Schiffmann,
- J. P. Werthenbach,
- F. Heintges-Kleinhofer,
- J. M. Seeger,
- M. Fritsch,
- S. D. Günther,
- S. Willenborg,
- S. Brodesser,
- C. Lucas,
- C. Jüngst,
- M. C. Albert,
- F. Schorn,
- A. Witt,
- C. T. Moraes,
- C. J. Bruns,
- M. Pasparakis,
- M. Krönke,
- S. A. Eming,
- O. Coutelle,
- H. Kashkar
Affiliations
- L. M. Schiffmann
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- J. P. Werthenbach
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- F. Heintges-Kleinhofer
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- J. M. Seeger
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- M. Fritsch
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- S. D. Günther
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- S. Willenborg
- Centre for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- S. Brodesser
- Lipidomics/Metabolomics Facility, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
- C. Lucas
- Lipidomics/Metabolomics Facility, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
- C. Jüngst
- Imaging Facility, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
- M. C. Albert
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- F. Schorn
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- A. Witt
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- C. T. Moraes
- Department of Neurology, Miller School of Medicine Miami, University of Miami
- C. J. Bruns
- Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne
- M. Pasparakis
- Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Centre for Molecular Medicine Cologne (CMMC), University of Cologne
- M. Krönke
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- S. A. Eming
- Centre for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- O. Coutelle
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- H. Kashkar
- Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital of Cologne, University of Cologne
- DOI
- https://doi.org/10.1038/s41467-020-17472-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
During angiogenesis the vasculature switches from a quiescent to a proliferative state. Here the authors show that mitochondrial respiration in endothelial cells controls angiogenesis during development, tumour growth and tissue repair.
