Nature Communications (Nov 2016)
Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease
- Walid Mottawea,
- Cheng-Kang Chiang,
- Marcus Mühlbauer,
- Amanda E. Starr,
- James Butcher,
- Turki Abujamel,
- Shelley A. Deeke,
- Annette Brandel,
- Hu Zhou,
- Shadi Shokralla,
- Mehrdad Hajibabaei,
- Ruth Singleton,
- Eric I. Benchimol,
- Christian Jobin,
- David R. Mack,
- Daniel Figeys,
- Alain Stintzi
Affiliations
- Walid Mottawea
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Cheng-Kang Chiang
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Marcus Mühlbauer
- Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Florida
- Amanda E. Starr
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- James Butcher
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Turki Abujamel
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Shelley A. Deeke
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Annette Brandel
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Hu Zhou
- Ottawa Institute of Systems Biology, University of Ottawa
- Shadi Shokralla
- Department of Integrative Biology, Biodiversity Institute of Ontario, University of Guelph
- Mehrdad Hajibabaei
- Department of Integrative Biology, Biodiversity Institute of Ontario, University of Guelph
- Ruth Singleton
- Children’s Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre and CHEO Research Institute
- Eric I. Benchimol
- Children’s Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre and CHEO Research Institute
- Christian Jobin
- Department of Medicine, Department of Infectious Diseases and Pathology, University of Florida
- David R. Mack
- Children’s Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre and CHEO Research Institute
- Daniel Figeys
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- Alain Stintzi
- Department of Biochemistry, Microbiology and Immunology, University of Ottawa
- DOI
- https://doi.org/10.1038/ncomms13419
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Crohn’s disease is associated with altered intestinal microbiota. Here, the authors show that the microbe Atopobium parvulumis associated with Crohn’s disease patients, triggers colitis in a mouse model, and that scavenging microbe-induced hydrogen sulfide improved symptoms in mice.
