Bidirectional lysosome transport: a balancing act between ARL8 effectors

Agnieszka A. Kendrick; Jenna R. Christensen

doi:10.1038/s41467-022-32965-y

Nature Communications (Sep 2022)

Bidirectional lysosome transport: a balancing act between ARL8 effectors

Agnieszka A. Kendrick,
Jenna R. Christensen

Affiliations

Agnieszka A. Kendrick: Department of Cellular and Molecular Medicine, University of California, San Diego
Jenna R. Christensen: Department of Cellular and Molecular Medicine, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-022-32965-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 3

Abstract

Read online

Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal