Phenomenon of synergism of immunodepressive drugs (addition of kempas to the protocol of immunodepression)

Abstract

Aim. To determine kempas ability to potentiate the action of simulneously used daklizumab. Material and methods. Kempas was given to 7 patients twice: 18-21 days before transplantation and on the day of transplantation after plasmapheresis. The control group consisted of 9 patients who received induction immunodepression only with daklizumab. By demographic and clinico-laboratory parameters the groups were identical. The assessment was made by duration of the interval between administration of daklizumab. Results. Patients given kempas had longer intervals between daklizumab administration (the difference was significant). Conclusion. Kempas potentiates an immunodepressive action of daklizumab

Keywords

• kidney transplantation
• immunosuppression
• induction