Indian Journal of Anaesthesia (Jan 2015)

The haemodynamic effects of the perioperative terlipressin infusion in living donor liver transplantation: A randomised controlled study

  • Nagwa Ibrahim,
  • Ashraf Hasanin,
  • Sabry Abd Allah,
  • Eman Sayed,
  • Mohamed Afifi,
  • Khaled Yassen,
  • Wesam Saber,
  • Magdy Khalil

DOI
https://doi.org/10.4103/0019-5049.153037
Journal volume & issue
Vol. 59, no. 3
pp. 156 – 164

Abstract

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Background and Aims: Liver disease is usually accompanied with a decline in systemic vascular resistance (SVR). We decided to assess effects of the peri-operative terlipressin infusion on liver donor liver transplantation recipients with respect to haemodynamics and renal parameters. Methods: After Ethical Committee approval for this prospective randomised controlled study, 50 recipients were enrolled and allotted to control (n = 25) or terlipressin group (n = 25) with simple randomisation method. Terlipressin was infused at 1.0 μg/kg/h and later titrated 1.0-4.0 μg/kg/h to maintain mean arterial pressure (MAP) >65 mmHg and SVR index 0.05) and was sustained post-operatively. Conclusion: Terlipressin improved SVR and MAP with less need for catecholamines particularly post-reperfusion. Terlipressin reduced PPV without hepatic artery vasoconstriction and improved post-operative UOP.

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