Nature Communications (Jan 2019)
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
- Rachel H. Clare,
- Catherine Bardelle,
- Paul Harper,
- W. David Hong,
- Ulf Börjesson,
- Kelly L. Johnston,
- Matthew Collier,
- Laura Myhill,
- Andrew Cassidy,
- Darren Plant,
- Helen Plant,
- Roger Clark,
- Darren A. N. Cook,
- Andrew Steven,
- John Archer,
- Paul McGillan,
- Sitthivut Charoensutthivarakul,
- Jaclyn Bibby,
- Raman Sharma,
- Gemma L. Nixon,
- Barton E. Slatko,
- Lindsey Cantin,
- Bo Wu,
- Joseph Turner,
- Louise Ford,
- Kirsty Rich,
- Mark Wigglesworth,
- Neil G. Berry,
- Paul M. O’Neill,
- Mark J. Taylor,
- Stephen A. Ward
Affiliations
- Rachel H. Clare
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Catherine Bardelle
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Paul Harper
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- W. David Hong
- Department of Chemistry, University of Liverpool
- Ulf Börjesson
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Kelly L. Johnston
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Matthew Collier
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Laura Myhill
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Andrew Cassidy
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Darren Plant
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Helen Plant
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Roger Clark
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Darren A. N. Cook
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Andrew Steven
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- John Archer
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Paul McGillan
- Department of Chemistry, University of Liverpool
- Sitthivut Charoensutthivarakul
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Jaclyn Bibby
- Department of Chemistry, University of Liverpool
- Raman Sharma
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Gemma L. Nixon
- Department of Chemistry, University of Liverpool
- Barton E. Slatko
- Genome Biology Division, New England Biolabs, Inc
- Lindsey Cantin
- Genome Biology Division, New England Biolabs, Inc
- Bo Wu
- Genome Biology Division, New England Biolabs, Inc
- Joseph Turner
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Louise Ford
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Kirsty Rich
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Mark Wigglesworth
- Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca
- Neil G. Berry
- Department of Chemistry, University of Liverpool
- Paul M. O’Neill
- Department of Chemistry, University of Liverpool
- Mark J. Taylor
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- Stephen A. Ward
- Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07826-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 8
Abstract
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-Wolbachia drugs.
