CENTRAL HEMODYNAMIC PARAMETERS IN PATIENTS WITH IDIOPATHIC ATRIAL FIBRILLATION

Abstract

In 27 patients with idiopathic atrial fibrillation (AF), echocardiography and the measurement of serum levels of NT-pro-BNP and endotoxin were performed before and after the restoration of sinus rhythm. After sinus rhythm restoration, the volume of left atrium (from 69,2±4,3 to 55,7±2,4 ml; р<0,01) and right atrium (from 57,2±4,1 to 48,2±2,5 ml; р<0,01) decreased; the levels of systolic (from 28,6±0,9 to 25,3±0,3 mm Hg; р<0,01) and diastolic (from 11,5±0,6 to 9,2±0,5 mm Hg; р<0,01) pressure in pulmonary artery were reduced; NT-proBNP concentration decreased from 1610±645 to 864±463 pg/ml (р<0,05); and endotoxin level decreased from 0,31±0,04 to 0,25±0,03 U/ml (р<0,01). The results obtained point to the association between AF and subclinical congestive disturbances of both systemic and pulmonary circulation.

Keywords

• idiopathic atrial fibrillation
• sinus rhythm restoration
• n-terminal pro-brain natriuretic peptide
• endotoxin
• level dynamics