World Allergy Organization Journal (Oct 2021)
ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments
- Carlo Lombardi, MD,
- Riccardo Asero, MD,
- Diego Bagnasco, MD,
- Francesco Blasi, MD,
- Matteo Bonini, MD,
- Mario Bussi, MD,
- Rikki F. Canevari, MD,
- Giorgio Walter Canonica, MD,
- Paolo Castelnuovo, MD,
- Lorenzo Cecchi, MD,
- Lorenzo Cosmi, MD,
- Matteo Gelardi, MD,
- Enrico Heffler, MD,
- Luciana Indinnimeo, MD,
- Massimo Landi, MD,
- Amelia Licari, MD,
- Francesco Liotta, MD,
- Alberto Macchi, MD,
- Luca Malvezzi, MD,
- Gianluigi Marseglia, MD,
- Claudio Micheletto, MD,
- Antonino Musarra, MD,
- Diego Peroni, MD,
- Giorgio Piacentini, MD,
- Venerino Poletti, MD,
- Luca Richeldi, MD,
- Angela Santoni, MD,
- Michele Schiappoli, MD,
- Gianenrico Senna, MD,
- Adriano Vaghi, MD,
- Alberto Villani, MD,
- Giovanni Passalacqua, MD
Affiliations
- Carlo Lombardi, MD
- Unit of Allergology, Clinical Immunology & Respiratory Diseases, Fondazione Poliambulanza, Brescia, Italy
- Riccardo Asero, MD
- Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, MI, Italy
- Diego Bagnasco, MD
- Allergy and Respiratory Diseases, IRCCS Policlinico S.Martino, University of Genoa, Italy
- Francesco Blasi, MD
- Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy
- Matteo Bonini, MD
- Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy
- Mario Bussi, MD
- Unità Operativa di Otorinolaringoiatria Ospedale Universitario I.R.C.C.S. San Raffaele, Milan, Italy
- Rikki F. Canevari, MD
- Dipartimento DISC Clinica Otorinolaringoiatra IRCCS Policlinico San Martino, Università di Genova, Italy
- Giorgio Walter Canonica, MD
- Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy
- Paolo Castelnuovo, MD
- DBSV, Clinica ORL, Università Insubria, ASST-settelaghi, HNS&FDR Center, Varese, Italy
- Lorenzo Cecchi, MD
- SOS Allergologia e Immunologia Clinica Prato, USL Toscana Centro, Italy
- Lorenzo Cosmi, MD
- Department of Experimental and Clinical Medicine, University of Florence, Italy
- Matteo Gelardi, MD
- Clinica Otorinolaringoiatrica, Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, Italy
- Enrico Heffler, MD
- Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy
- Luciana Indinnimeo, MD
- Università degli Studi di Roma “Sapienza”, Direttore Scientifico di Area Pediatrica, Società Italiana di Pediatria, Italy
- Massimo Landi, MD
- Pediatric National Healthcare System, Turin, Institute of Biomedical Research and Innovation Palermo, Italy
- Amelia Licari, MD
- Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy
- Francesco Liotta, MD
- Department of Experimental and Clinical Medicine, University of Florence, Italy
- Alberto Macchi, MD
- Clinica ORL, Asst Settelaghi Varese, Università degli Studi dell’ Insubria, Varese, Italy
- Luca Malvezzi, MD
- Otorhinolaryngology Unit, Humanitas University, Humanitas Clinical & Research Center, Rozzano, MI, Italy
- Gianluigi Marseglia, MD
- Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy
- Claudio Micheletto, MD
- UOC Pneumologia, Azienda Ospedaliera Universitaria, Verona, Italy
- Antonino Musarra, MD
- Servizio di Allergologia, Casa della Salute di Scilla, ASP di Reggio Calabria, Italy
- Diego Peroni, MD
- Pediatrics, Dept. of Experimental Medicine, University of Pisa, Italy
- Giorgio Piacentini, MD
- Dipartimento di Scienze Chirurgiche, Odontostomatologiche e Materno-Infantili Università di Verona, Italy
- Venerino Poletti, MD
- Dipartimento Toracico Azienda USL ROMAGNA (I), Italy
- Luca Richeldi, MD
- UOC DI PNEUMOLOGIA, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy
- Angela Santoni, MD
- Dipartimento di Medicina Molecolare, Università; “Sapienza”, Roma, Italy
- Michele Schiappoli, MD
- Asthma Center and Allergy Unit, University of Verona and General Hospital, Verona, Italy
- Gianenrico Senna, MD
- Asthma Center and Allergy Unit, University of Verona and General Hospital, Verona, Italy
- Adriano Vaghi, MD
- ASST Rodhense Pneumologia, Italy
- Alberto Villani, MD
- Unità Operativa Complessa di Pediatria Generale e Malattie Infettive, Ospedale Pediatrico Bambino Gesù, Roma, Italy
- Giovanni Passalacqua, MD
- Allergy and Respiratory Diseases, IRCCS Policlinico S.Martino, University of Genoa, Italy; Corresponding author. Allergy and Respiratory DiseasesIRCCS Policlinico San Martino University of Genoa, Italy
- Journal volume & issue
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Vol. 14,
no. 10
p. 100592
Abstract
In the recent years, it was recognized that type-2 inflammation links many forms of nasal polyposis with severe asthma. Thus, some biological drugs developed for severe asthma appeared to exert an effect on nasal polyposis. So far, there are several trials supporting this concept; therefore, some monoclonal antibodies for severe asthma were assessed also in polyposis, with promising results. Since different specialists are involved in the management of nasal polyposis (eg, pulmonologists, ENT, allergists), it was felt that an educational and informative document was needed to better identify the indications of biologicals in nasal polyposis. We collected the main Italian Scientific Societies, and prepared (under the Allergic Rhinitis and its Impact on Asthma, ARIA) a document endorsed by all Societies, to provide a provisional statement for the future use of monoclonal antibodies as a medical treatment for polyposis. It is the first nationwide endorsed document on this aspect. The current pathogenic knowledge and the experimental evidence are herein reviewed, and some suggestions for a correct prescription and follow-up are provided.
