Frontiers in Bioscience-Landmark (Jan 2020)

miR-1 inhibits migration of gastric cancer cells

  • Xiu-qing Lin,
  • Wei Wu,
  • Xin Chen,
  • Ren-pin Chen,
  • Fang Wu,
  • Zhou-feng Chen,
  • Er-jiong Huang,
  • Chao Chen

DOI
https://doi.org/10.2741/4813
Journal volume & issue
Vol. 25, no. 3
pp. 452 – 462

Abstract

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Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion.

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