A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Rodrigo Cataldi; Sean Chia; Katarina Pisani; Francesco S. Ruggeri; Catherine K. Xu; Tomas Šneideris; Michele Perni; Sunehera Sarwat; Priyanka Joshi; Janet R. Kumita; Sara Linse; Johnny Habchi; Tuomas P. J. Knowles; Benedetta Mannini; Christopher M. Dobson; Michele Vendruscolo

doi:10.1038/s42003-020-01490-3

Communications Biology (Jan 2021)

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

Rodrigo Cataldi,
Sean Chia,
Katarina Pisani,
Francesco S. Ruggeri,
Catherine K. Xu,
Tomas Šneideris,
Michele Perni,
Sunehera Sarwat,
Priyanka Joshi,
Janet R. Kumita,
Sara Linse,
Johnny Habchi,
Tuomas P. J. Knowles,
Benedetta Mannini,
Christopher M. Dobson,
Michele Vendruscolo

Affiliations

Rodrigo Cataldi: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Sean Chia: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Katarina Pisani: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Francesco S. Ruggeri: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Catherine K. Xu: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Tomas Šneideris: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Michele Perni: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Sunehera Sarwat: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Priyanka Joshi: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Janet R. Kumita: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Sara Linse: Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University
Johnny Habchi: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Tuomas P. J. Knowles: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Benedetta Mannini: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Christopher M. Dobson: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Michele Vendruscolo: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge

DOI: https://doi.org/10.1038/s42003-020-01490-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

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Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic calcium levels and generating reactive oxygen species. This study connects Aβ aggregation with processes regulating cellular homeostasis in the brain.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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