Genetics and Molecular Biology ()

VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy

  • Ronaldo Celerino da Silva,
  • Neyla Maria Pereira Alves,
  • Jorge José de Souza Pereira,
  • Antonio Victor Campos Coelho,
  • Luiz Cláudio Arraes,
  • Lucas André Cavalcanti Brandão,
  • Sergio Crovella,
  • Jaqueline de Azevêdo Silva

DOI
https://doi.org/10.1590/1678-4685-gmb-2017-0289

Abstract

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Abstract Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.

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