Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta

Yang Chen; Sujuan Yang; Sara Lovisa; Catherine G. Ambrose; Kathleen M. McAndrews; Hikaru Sugimoto; Raghu Kalluri

doi:10.1038/s41467-021-27563-3

Nature Communications (Dec 2021)

Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta

Yang Chen,
Sujuan Yang,
Sara Lovisa,
Catherine G. Ambrose,
Kathleen M. McAndrews,
Hikaru Sugimoto,
Raghu Kalluri

Affiliations

Yang Chen: Department of Cancer Biology, University of Texas MD Anderson Cancer Center
Sujuan Yang: Department of Cancer Biology, University of Texas MD Anderson Cancer Center
Sara Lovisa: Department of Cancer Biology, University of Texas MD Anderson Cancer Center
Catherine G. Ambrose: Department of Orthopaedic Surgery, University of Texas Health Science Center at Houston
Kathleen M. McAndrews: Department of Cancer Biology, University of Texas MD Anderson Cancer Center
Hikaru Sugimoto: Department of Cancer Biology, University of Texas MD Anderson Cancer Center
Raghu Kalluri: Department of Cancer Biology, University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-021-27563-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Collagen is the most abundant protein in the human body. Here, the authors show that different classes of fibroblasts produce collagen of unique functions with different impacts on embryo development and bone formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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