Identification of the role of TG2 on the expression of TGF-β, TIMP-1 and TIMP-2 in aged skin

Abstract

Transglutaminase 2 (TG2) is a unique protein having enzymatic and nonenzymatic functions that have been implicated in various biological and pathological processes such as cell survival and apoptosis, cell signaling, differentiation, adhesion and migration, wound healing and inflammation. As reported in previous studies, TG2 expression and activity increase by age suggesting that TG2 possibly has roles in cellular aging process. In this study, we aimed to explore the role of TG2 in chronological skin aging through its impact on the expression of some important extracellular matrix (ECM) proteins including TGF-β, TIMP-1 and TIMP-2.

Keywords

• skin aging
• dermal fibroblasts
• extracellular matrix
• transglutaminase 2
• crosslinking activity