Nature Communications (Jun 2017)
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma
- Sam Behjati,
- Patrick S. Tarpey,
- Kerstin Haase,
- Hongtao Ye,
- Matthew D. Young,
- Ludmil B. Alexandrov,
- Sarah J. Farndon,
- Grace Collord,
- David C. Wedge,
- Inigo Martincorena,
- Susanna L. Cooke,
- Helen Davies,
- William Mifsud,
- Mathias Lidgren,
- Sancha Martin,
- Calli Latimer,
- Mark Maddison,
- Adam P. Butler,
- Jon W. Teague,
- Nischalan Pillay,
- Adam Shlien,
- Ultan McDermott,
- P. Andrew Futreal,
- Daniel Baumhoer,
- Olga Zaikova,
- Bodil Bjerkehagen,
- Ola Myklebost,
- M. Fernanda Amary,
- Roberto Tirabosco,
- Peter Van Loo,
- Michael R. Stratton,
- Adrienne M. Flanagan,
- Peter J. Campbell
Affiliations
- Sam Behjati
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Patrick S. Tarpey
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Kerstin Haase
- The Francis Crick Institute
- Hongtao Ye
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Matthew D. Young
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Ludmil B. Alexandrov
- Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory
- Sarah J. Farndon
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Grace Collord
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- David C. Wedge
- Oxford Big Data Institute and Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Roosevelt Drive
- Inigo Martincorena
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Susanna L. Cooke
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Helen Davies
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- William Mifsud
- UCL Great Ormond Street Institute of Child Health
- Mathias Lidgren
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Sancha Martin
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Calli Latimer
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Mark Maddison
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Adam P. Butler
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Jon W. Teague
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Nischalan Pillay
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Adam Shlien
- Department of Paediatric Laboratory Medicine, The Hospital for Sick Children
- Ultan McDermott
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- P. Andrew Futreal
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Daniel Baumhoer
- Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel
- Olga Zaikova
- Oslo University Hospital
- Bodil Bjerkehagen
- Oslo University Hospital
- Ola Myklebost
- Oslo University Hospital
- M. Fernanda Amary
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Roberto Tirabosco
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Peter Van Loo
- The Francis Crick Institute
- Michael R. Stratton
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Adrienne M. Flanagan
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Peter J. Campbell
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- DOI
- https://doi.org/10.1038/ncomms15936
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles characterized by chromothripsis-amplification.
