Nature Communications (May 2016)

Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories

  • Siobhan S. Pattwell,
  • Conor Liston,
  • Deqiang Jing,
  • Ipe Ninan,
  • Rui R. Yang,
  • Jonathan Witztum,
  • Mitchell H. Murdock,
  • Iva Dincheva,
  • Kevin G. Bath,
  • B. J. Casey,
  • Karl Deisseroth,
  • Francis S. Lee

DOI
https://doi.org/10.1038/ncomms11475
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Flexible fear-related responses may be advantageous in adolescence. Here the authors use microprisms to image prefrontal cortical spine maturation across development and report that plasticity in adolescent fear extinction responses is associated with dynamic reorganization in the amygdalahippocampal-PFC circuit.