International Journal of Molecular Sciences (Jul 2014)

Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection

  • Lili Shen,
  • Mulong Du,
  • Chun Wang,
  • Dongying Gu,
  • Meilin Wang,
  • Qi Zhang,
  • Tingting Zhao,
  • Xunlei Zhang,
  • Yongfei Tan,
  • Xinying Huo,
  • Weida Gong,
  • Zhi Xu,
  • Jinfei Chen,
  • Zhengdong Zhang

DOI
https://doi.org/10.3390/ijms150712764
Journal volume & issue
Vol. 15, no. 7
pp. 12764 – 12777

Abstract

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This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069–2.911, p = 0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations.

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