Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

Min-Ying Lin; Hsin-Hua Hsieh; Jyh-Cheng Chen; Chuan-Lin Chen; Nin-Chu Sheu; Wen-Sheng Huang; Shinn-Ying Ho; Ting-Wen Chen; Yi-Jang Lee; Chun-Yi Wu

doi:10.3390/pharmaceutics13111903

Pharmaceutics (Nov 2021)

Brachytherapy Approach Using <sup>177</sup>Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model

Min-Ying Lin,
Hsin-Hua Hsieh,
Jyh-Cheng Chen,
Chuan-Lin Chen,
Nin-Chu Sheu,
Wen-Sheng Huang,
Shinn-Ying Ho,
Ting-Wen Chen,
Yi-Jang Lee,
Chun-Yi Wu

Affiliations

Min-Ying Lin: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Hsin-Hua Hsieh: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Jyh-Cheng Chen: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Chuan-Lin Chen: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Nin-Chu Sheu: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Wen-Sheng Huang: Department of Nuclear Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan
Shinn-Ying Ho: Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu Branch, Hsinchu 30068, Taiwan
Ting-Wen Chen: Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu Branch, Hsinchu 30068, Taiwan
Yi-Jang Lee: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan
Chun-Yi Wu: Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei Branch, Taipei 112, Taiwan

DOI: https://doi.org/10.3390/pharmaceutics13111903
Journal volume & issue: Vol. 13, no. 11
p. 1903

Abstract

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Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β−-emitter 177Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (177Lu-DTPA-pAuNS) used in surface-enhanced Raman scattering and photothermal therapy (PTT). The accumulation and therapeutic efficacy of 177Lu-DTPA-pAuNS were compared with those of 177Lu-DTPA on an orthotopic HNSCC tumor model. The SPECT/CT imaging and biodistribution studies showed that 177Lu-DTPA-pAuNS can be accumulated in the tumor up to 15 days, but 177Lu-DTPA could not be detected at 24 h after injection. The tumor viability and growth were suppressed by injected 177Lu-DTPA-pAuNS but not nonconjugated 177Lu-DTPA, as evaluated by bioluminescent imaging. The radiation-absorbed dose of the normal organ was the highest in the liver (0.33 mSv/MBq) estimated in a 73 kg adult, but that of tumorsphere (0.5 g) was 3.55 mGy/MBq, while intravenous injection of 177Lu-DTPA-pAuNS resulted in 1.97 mSv/MBq and 0.13 mGy/MBq for liver and tumorsphere, respectively. We also observed further enhancement of tumor-suppressive effects by a combination of 177Lu-DTPA-pAuNS and PTT compared to 177Lu-DTPA-pAuNS alone. In conclusion, 177Lu-DTPA-pAuNS may be considered as a potential radiopharmaceutical agent for HNSCC brachytherapy.

Published in Pharmaceutics

ISSN: 1999-4923 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceutics/

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