Killing by Type VI secretion drives genetic phase separation and correlates with increased cooperation

Luke McNally; Eryn Bernardy; Jacob Thomas; Arben Kalziqi; Jennifer Pentz; Sam P. Brown; Brian K. Hammer; Peter J. Yunker; William C. Ratcliff

doi:10.1038/ncomms14371

Nature Communications (Feb 2017)

Killing by Type VI secretion drives genetic phase separation and correlates with increased cooperation

Luke McNally,
Eryn Bernardy,
Jacob Thomas,
Arben Kalziqi,
Jennifer Pentz,
Sam P. Brown,
Brian K. Hammer,
Peter J. Yunker,
William C. Ratcliff

Affiliations

Luke McNally: Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh
Eryn Bernardy: School of Biological Sciences, Georgia Institute of Technology
Jacob Thomas: School of Biological Sciences, Georgia Institute of Technology
Arben Kalziqi: School of Physics, Georgia Institute of Technology
Jennifer Pentz: School of Biological Sciences, Georgia Institute of Technology
Sam P. Brown: School of Biological Sciences, Georgia Institute of Technology
Brian K. Hammer: School of Biological Sciences, Georgia Institute of Technology
Peter J. Yunker: School of Physics, Georgia Institute of Technology
William C. Ratcliff: School of Biological Sciences, Georgia Institute of Technology

DOI: https://doi.org/10.1038/ncomms14371
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

The Type VI Secretory System (T6SS) is used by some bacteria to kill non-kin competitors. Here, McNally and colleagues combine mathematical modelling, experiments withVibrio choleraand phylogenetic analysis to show that by eliminating nearby non-kin the T6SS may also favour cooperation among kin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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