Communications Biology (Jul 2021)

Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform

  • Yifeng Xia,
  • Xiaodong Ji,
  • In Sock Jang,
  • Christine Surka,
  • Christy Hsu,
  • Kai Wang,
  • Mark Rolfe,
  • Neil Bence,
  • Gang Lu

DOI
https://doi.org/10.1038/s42003-021-02352-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 7

Abstract

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Xia et al. report the development and optimization of a high-throughput screening platform to systematically determine cancer cell sensitivity to pharmacological and genetic perturbations, BMS-PRISM, based on PRISM and high-throughput CRISPR/Cas9 loss-of-function screen technologies using cell line barcoding.