<i>Enterovirus D</i>: A Small but Versatile Species

Ines Cordeiro Filipe; Mariana Soares Guedes; Evgeny M. Zdobnov; Caroline Tapparel

doi:10.3390/microorganisms9081758

Microorganisms (Aug 2021)

<i>Enterovirus D</i>: A Small but Versatile Species

Ines Cordeiro Filipe,
Mariana Soares Guedes,
Evgeny M. Zdobnov,
Caroline Tapparel

Affiliations

Ines Cordeiro Filipe: Department of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, Switzerland
Mariana Soares Guedes: Department of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, Switzerland
Evgeny M. Zdobnov: Department of Genetic Medicine and Development, Switzerland and Swiss Institute of Bioinformatics, University of Geneva, 1206 Geneva, Switzerland
Caroline Tapparel: Department of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, Switzerland

DOI: https://doi.org/10.3390/microorganisms9081758
Journal volume & issue: Vol. 9, no. 8
p. 1758

Abstract

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Enteroviruses (EVs) from the D species are the causative agents of a diverse range of infectious diseases in spite of comprising only five known members. This small clade has a diverse host range and tissue tropism. It contains types infecting non-human primates and/or humans, and for the latter, they preferentially infect the eye, respiratory tract, gastrointestinal tract, and nervous system. Although several Enterovirus D members, in particular EV-D68, have been associated with neurological complications, including acute myelitis, there is currently no effective treatment or vaccine against any of them. This review highlights the peculiarities of this viral species, focusing on genome organization, functional elements, receptor usage, and pathogenesis.

Published in Microorganisms

ISSN: 2076-2607 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.mdpi.com/journal/microorganisms

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Abstract

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