Chinese Journal of Lung Cancer (Dec 2010)
Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma
Abstract
Background and objective The incidence of lung adenocarcinoma increases rapidly, and IGF-IR is the key mediator of several growth factors signal transduction, therefore it plays an important role in the proliferation and differentiation of cancer cell. The aim of this study is to detect the expression of IGF-IR in lung adenocarcinoma and to evaluate its implication for the clinicopathological factors and prognosis of patients with this disease. Methods The IGF-IR expression was detected by immunohistochemical staining. Correlations between IGF-IR expression with clinicopathological factors were analyzed using the Chi-squared test. The Kaplan-Meier method was used to calculate the overall patient survival rate, and the difference in survival curves was evaluated using a Log-rank test. Univariate and multivariate analysis was carried out using the Cox proportional-hazard model. Results In 126 cases of tumor sections tested, IGF-IR were detected in 89 cases. Statistical analysis revealed that the IGF-IR expression was related to tumor size and T stage, while there were no relations between IGFIR expression and age, gender, smoking, pathological stages, and differentiation. Cox analysis indicated that metastasis and chemotherapy efficacy were the prognostic factors in these patients, while IGF-IR expression was not the independent prognostic factor. Conclusion The IGF-IR expression is related to tumor size and T stage, while there is no relation between IGF-IR expression and prognosis.
