Molecular & Cellular Oncology (Sep 2019)

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

  • Patricia Santofimia-Castaño,
  • Bruno Rizzuti,
  • Yi Xia,
  • Olga Abian,
  • Ling Peng,
  • Adrián Velázquez-Campoy,
  • Juan L. Iovanna,
  • José L. Neira

DOI
https://doi.org/10.1080/23723556.2019.1612678
Journal volume & issue
Vol. 6, no. 5

Abstract

Read online

Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).

Keywords