Manganese-driven CoQ deficiency

Jutta Diessl; Jens Berndtsson; Filomena Broeskamp; Lukas Habernig; Verena Kohler; Carmela Vazquez-Calvo; Arpita Nandy; Carlotta Peselj; Sofia Drobysheva; Ludovic Pelosi; F.-Nora Vögtle; Fabien Pierrel; Martin Ott; Sabrina Büttner

doi:10.1038/s41467-022-33641-x

Nature Communications (Oct 2022)

Manganese-driven CoQ deficiency

Jutta Diessl,
Jens Berndtsson,
Filomena Broeskamp,
Lukas Habernig,
Verena Kohler,
Carmela Vazquez-Calvo,
Arpita Nandy,
Carlotta Peselj,
Sofia Drobysheva,
Ludovic Pelosi,
F.-Nora Vögtle,
Fabien Pierrel,
Martin Ott,
Sabrina Büttner

Affiliations

Jutta Diessl: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Jens Berndtsson: Department of Biochemistry and Biophysics, Stockholm University
Filomena Broeskamp: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Lukas Habernig: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Verena Kohler: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Carmela Vazquez-Calvo: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Arpita Nandy: Institute of Biochemistry and Molecular Biology, ZBMZ, University of Freiburg
Carlotta Peselj: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Sofia Drobysheva: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
Ludovic Pelosi: Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC
F.-Nora Vögtle: Institute of Biochemistry and Molecular Biology, ZBMZ, University of Freiburg
Fabien Pierrel: Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC
Martin Ott: Department of Biochemistry and Biophysics, Stockholm University
Sabrina Büttner: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

DOI: https://doi.org/10.1038/s41467-022-33641-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal