Clonal diversity predicts persistence of SARS-CoV-2 epitope-specific T-cell response

Ksenia V. Zornikova; Alexandra Khmelevskaya; Savely A. Sheetikov; Dmitry O. Kiryukhin; Olga V. Shcherbakova; Aleksei Titov; Ivan V. Zvyagin; Grigory A. Efimov

doi:10.1038/s42003-022-04250-7

Communications Biology (Dec 2022)

Clonal diversity predicts persistence of SARS-CoV-2 epitope-specific T-cell response

Ksenia V. Zornikova,
Alexandra Khmelevskaya,
Savely A. Sheetikov,
Dmitry O. Kiryukhin,
Olga V. Shcherbakova,
Aleksei Titov,
Ivan V. Zvyagin,
Grigory A. Efimov

Affiliations

Ksenia V. Zornikova: National Medical Research Center for Hematology
Alexandra Khmelevskaya: National Medical Research Center for Hematology
Savely A. Sheetikov: National Medical Research Center for Hematology
Dmitry O. Kiryukhin: National Medical Research Center for Hematology
Olga V. Shcherbakova: National Medical Research Center for Hematology
Aleksei Titov: National Medical Research Center for Hematology
Ivan V. Zvyagin: Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Grigory A. Efimov: National Medical Research Center for Hematology

DOI: https://doi.org/10.1038/s42003-022-04250-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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The clonotypes of CD8+ T cells specific to 9 SARS-CoV-2 epitopes are identified from COVID-19 convalescent patients and the longitudinal study of these clonotypes reveals that T cell persistence correlates with TCR diversity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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