Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

Sara Zocher; Rupert W. Overall; Mathias Lesche; Andreas Dahl; Gerd Kempermann

doi:10.1038/s41467-021-23993-1

Nature Communications (Jun 2021)

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

Sara Zocher,
Rupert W. Overall,
Mathias Lesche,
Andreas Dahl,
Gerd Kempermann

Affiliations

Sara Zocher: German Center for Neurodegenerative Diseases (DZNE) Dresden
Rupert W. Overall: German Center for Neurodegenerative Diseases (DZNE) Dresden
Mathias Lesche: Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
Andreas Dahl: Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
Gerd Kempermann: German Center for Neurodegenerative Diseases (DZNE) Dresden

DOI: https://doi.org/10.1038/s41467-021-23993-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Here the authors provide evidence that environmental enrichment delays age-related DNA methylation alterations in the mouse hippocampus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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