Future Science OA (Aug 2020)

Development of thrombocytopenia is associated with improved survival in patients treated with immunotherapy

  • Hussein A Assi,
  • Adam S Asch,
  • Michael Machiorlatti,
  • Sara K Vesely,
  • Sami Ibrahimi

DOI
https://doi.org/10.2144/fsoa-2020-0021
Journal volume & issue
Vol. 6, no. 7

Abstract

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Background: Immune-related adverse events are associated with efficacy of immune checkpoint inhibitors (ICIs). We hypothesize that immune-mediated thrombocytopenia could be a biomarker for response to ICIs. Materials & methods: This retrospective study included 215 patients with metastatic malignancies treated with ICIs. Patients were stratified by nadir platelet count. Outcomes of interest were progression-free survival and overall survival. Results: On multivariate analysis, grade 1 thrombocytopenia was positively associated with overall survival compared with patients who did not develop thrombocytopenia (hazard ratio [HR]= 0.28 [95% CI: 0.13–0.60]; p = 0.001), while grade 2–4 thrombocytopenia was not (HR= 0.36 [95% CI: 0.13–1.04]; p = 0.060). There was no association between degree of thrombocytopenia and progression-free survival. Conclusion: Follow-up studies are warranted to substantiate the predictive significance of thrombocytopenia in patients receiving ICIs.

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