Bv8-Like Toxin from the Frog Venom of <i>Amolops jingdongensis</i> Promotes Wound Healing via the Interleukin-1 Signaling Pathway

Abstract

Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds healing of mice model by promoting the initiation and the termination of inflammatory phase. Moreover, Bv8-AJ exerted strong proliferative effect on fibroblasts and keratinocytes isolated from newborn mice by activating interleukin (IL)-1 production. Our findings indicate that Bv8 is a potent wound healing regulator and may reveal the mechanism of rapid wound-healing in amphibian skins.

Keywords

• bv8
• <i>amolops jingdongensis</i>
• wound healing
• interleukin-1
• keratinocytes
• fibroblasts