Frontiers in Endocrinology (Oct 2023)
Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
- Vedrana Ivić,
- Milorad Zjalić,
- Senka Blažetić,
- Matija Fenrich,
- Irena Labak,
- Rudolf Scitovski,
- Kálmán Ferenc Szűcs,
- Eszter Ducza,
- Tamás Tábi,
- Fruzsina Bagamery,
- Éva Szökő,
- Rosemary Vuković,
- Alen Rončević,
- Alen Rončević,
- Dario Mandić,
- Dario Mandić,
- Željko Debeljak,
- Željko Debeljak,
- Monika Berecki,
- Marta Balog,
- Adrienn Seres-Bokor,
- Anita Sztojkov-Ivanov,
- Judit Hajagos-Tóth,
- Srećko Gajović,
- Alen Imširović,
- Marina Bakula,
- Solomiia Mahiiovych,
- Robert Gaspar,
- Sandor G. Vari,
- Marija Heffer
Affiliations
- Vedrana Ivić
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Milorad Zjalić
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Senka Blažetić
- Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Matija Fenrich
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Irena Labak
- Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Rudolf Scitovski
- School of Applied Mathematics and Computer Science, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Kálmán Ferenc Szűcs
- Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary
- Eszter Ducza
- Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
- Tamás Tábi
- Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary
- Fruzsina Bagamery
- Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary
- Éva Szökő
- Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary
- Rosemary Vuković
- Department of Biology, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Alen Rončević
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Alen Rončević
- Department of Neurosurgery, Osijek University Hospital, Osijek, Croatia
- Dario Mandić
- Clinical Institute of Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia
- Dario Mandić
- Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Željko Debeljak
- Clinical Institute of Laboratory Diagnostics, Osijek University Hospital, Osijek, Croatia
- Željko Debeljak
- 0Department of Pharmacology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Monika Berecki
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Marta Balog
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Adrienn Seres-Bokor
- Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
- Anita Sztojkov-Ivanov
- Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
- Judit Hajagos-Tóth
- Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary
- Srećko Gajović
- 1Croatian Institute for Brain Research, and BIMIS - Biomedical Research Institute Šalata, University of Zagreb School of Medicine, Zagreb, Croatia
- Alen Imširović
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- Marina Bakula
- 2Department of Clinical Pathology and Forensic Medicine, Osijek University Hospital, Osijek, Croatia
- Solomiia Mahiiovych
- 3Department of Therapy № 1 and Medical Diagnostics, Hematology and Transfusiology, Faculty of Postgraduate Education, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
- Robert Gaspar
- Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary
- Sandor G. Vari
- 4Cedars-Sinai Medical Center, International Research and Innovation in Medicine Program, Los Angeles, CA, United States
- Marija Heffer
- Department of Medical Biology and Genetics, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
- DOI
- https://doi.org/10.3389/fendo.2023.1181064
- Journal volume & issue
-
Vol. 14
Abstract
Aim/IntroductionThe study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes.MethodsElderly Sprague–Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old.ResultsUnexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes.ConclusionLiraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.
Keywords
