Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors

Peiyi Ye; Xia Li; Binbin Cui; Shihao Song; Fangfang Shen; Xiayu Chen; Gerun Wang; Xiaofan Zhou; Yinyue Deng

doi:10.1038/s42003-022-03451-4

Communications Biology (May 2022)

Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors

Peiyi Ye,
Xia Li,
Binbin Cui,
Shihao Song,
Fangfang Shen,
Xiayu Chen,
Gerun Wang,
Xiaofan Zhou,
Yinyue Deng

Affiliations

Peiyi Ye: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Xia Li: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Binbin Cui: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Shihao Song: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Fangfang Shen: Integrative Microbiology Research Center, College of Plant Protection, South China Agricultural University
Xiayu Chen: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Gerun Wang: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University
Xiaofan Zhou: Integrative Microbiology Research Center, College of Plant Protection, South China Agricultural University
Yinyue Deng: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University

DOI: https://doi.org/10.1038/s42003-022-03451-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 9

Abstract

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Proline utilization A (PutA) is a global transcriptional regulator besides its known role in proline oxidation, responding to its substrate and cofactors to coordinate between bacterial physiology and pathogenicity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal