Антибиотики и Химиотерапия (May 2020)
Substantiation of Antioxidant Drug Use for the Prevention of Community-Acquired Pneumonia in Military Personnel Serving in Conscription
Abstract
Stress is one of the reasons for the decrease in body resistance of young recruits in military personnel. A significant role of activation of lipid peroxidation (LPO) processes was established according to the results of complex studies of structural disorders of the lung tissue under the influence of stress factors. LPO is a free radical oxidation of polyunsaturated fatty acids in biological systems, which is one of the main processes of causing damage to biological membranes and other components of the cell. The pathological effect of reactive oxygen species, hydroxyl, alkoxy, and other free radicals leads to a decrease in the amount of surfactant, pulmonary tissue edema, impaired microcirculation, reduction in the receptor mechanisms of the tracheobronchial tree cells, which ultimately leads to the disruption of the respiratory structure of the lungs and local resistance system. Antioxidants serve as the protective system of the body against LPO processes. They are a group of endogenous and exogenous biologically active substances that can block the action of reactive oxygen species. Studies have shown that the preventive introduction of antioxidants reduces the pathological effect of reactive oxygen species. For example, the introduction of a complex of substances such as a-tocopherol, ascorbic acid, as well as the complex preparation Cytoflavin®, helps to maintain the proper amount of surfactant, reduce pulmonary edema, and prevent microcirculation disorders. Thus, the preventive use of antioxidant drugs contributes to the development of pulmonoprotective action, preserving the activity of the local immunity system, which, in turn, leads to the prevention of the development of community-acquired pneumonia in military personnel undergoing a period of adaptation to military service.
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