Nature Communications (Aug 2016)
Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors
- Helena Escuin-Ordinas,
- Shuoran Li,
- Michael W. Xie,
- Lu Sun,
- Willy Hugo,
- Rong Rong Huang,
- Jing Jiao,
- Felipe Meira de-Faria,
- Susan Realegeno,
- Paige Krystofinski,
- Ariel Azhdam,
- Sara Marie D. Komenan,
- Mohammad Atefi,
- Begoña Comin-Anduix,
- Matteo Pellegrini,
- Alistair J. Cochran,
- Robert L. Modlin,
- Harvey R. Herschman,
- Roger S. Lo,
- William H. McBride,
- Tatiana Segura,
- Antoni Ribas
Affiliations
- Helena Escuin-Ordinas
- Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)
- Shuoran Li
- Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA)
- Michael W. Xie
- Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, Los Angeles (UCLA)
- Lu Sun
- Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)
- Willy Hugo
- Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)
- Rong Rong Huang
- Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA)
- Jing Jiao
- Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA)
- Felipe Meira de-Faria
- Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA)
- Susan Realegeno
- Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles (UCLA)
- Paige Krystofinski
- Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)
- Ariel Azhdam
- Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)
- Sara Marie D. Komenan
- Division of Surgical Oncology, Department of Surgery
- Mohammad Atefi
- Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)
- Begoña Comin-Anduix
- Division of Surgical Oncology, Department of Surgery
- Matteo Pellegrini
- Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles (UCLA)
- Alistair J. Cochran
- Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA)
- Robert L. Modlin
- Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)
- Harvey R. Herschman
- Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA)
- Roger S. Lo
- Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA)
- William H. McBride
- Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, Los Angeles (UCLA)
- Tatiana Segura
- Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA)
- Antoni Ribas
- Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA)
- DOI
- https://doi.org/10.1038/ncomms12348
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
BRAF inhibitors often show skin-hyperproliferative side effects in melanoma patients. Here, the authors demonstrate that BRAF inhibitors can be used to enhance skin wound healing through the MAPK- ERK pathway activation that positively regulates the proliferation of keratinocytes.
