Virus persistence in atherosclerotic plaques in patients after carotid endarterectomy

Abstract

Objective ‒ to mark the quantity of herpes and flu infection detection of the none-stabil and stabil atherosclerotic (AS) plaques in patients with ischemic stroke (IS)/TIA and with the progressing AS and in the anamnesis after carotid endarterectomy. Materials and methods. 103 patients with IS/TIA after carotid endarterectomy were examined: 67 males 42‒82 years old (average age ‒ 66,1±1,4 years), 36 females 44‒81 years old (average age ‒ 63,0±1,3 years). Average age ‒ 65,1± 0,9 year. We examined the width of intima-media complex, presence of AS plaques, their constitution. Results. Among all viruses investigated with transfection and polymerase chain reaction in AS plaques and blood after carotid endarterectomy (HSV1,2, ЕВV, CMV, HHV6), the most prefer are with CMV and associated CMV + HSV1, CMV + HSV2, where patients, hwo have HHV6 and associated HSV1 + HHV6, HHV6 + HSV1 + HSV2. Conclusions. Presentation of CMV and associated CMV + HSV1, CMV + HSV2 increases the risk of development of the hypoechoic none-stabil AS plaques of internal carotid artery (ICA). Presentation of HHV6 and associated HSV1 + HHV6, HSV1 + HSV2 + HHV6 in AS plaques of ICA increases the relative risk of development of severe stenosis in the patients with symptomatic stenosis. The investigation confirms the necessary of periodical administration at exclusion of the stenosis of ICA.

Keywords

• carotid endarterectomy; atherosclerotic plaques; stenosis.