Communications Biology (Feb 2021)
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival
- Sandeep K. Singhal,
- Jung S. Byun,
- Samson Park,
- Tingfen Yan,
- Ryan Yancey,
- Ambar Caban,
- Sara Gil Hernandez,
- Stephen M. Hewitt,
- Heike Boisvert,
- Stephanie Hennek,
- Mark Bobrow,
- Md Shakir Uddin Ahmed,
- Jason White,
- Clayton Yates,
- Andrew Aukerman,
- Rami Vanguri,
- Rohan Bareja,
- Romina Lenci,
- Paula Lucia Farré,
- Adriana De Siervi,
- Anna María Nápoles,
- Nasreen Vohra,
- Kevin Gardner
Affiliations
- Sandeep K. Singhal
- Department of Pathology, School of Medicine and Health Sciences, Department of Computer Science, School of Electrical Engineering and Computer Science, University of North Dakota
- Jung S. Byun
- Division of Intramural Research, National Institutes of Minority Health and Health Disparities, National Institutes of Health
- Samson Park
- Division of Intramural Research, National Institutes of Minority Health and Health Disparities, National Institutes of Health
- Tingfen Yan
- Division of Intramural Research, National Institutes of Minority Health and Health Disparities, National Institutes of Health
- Ryan Yancey
- Department of Pathology and Cell Biology, Columbia University Irvine Medical Center
- Ambar Caban
- Department of Pathology and Cell Biology, Columbia University Irvine Medical Center
- Sara Gil Hernandez
- Division of Intramural Research, National Institutes of Minority Health and Health Disparities, National Institutes of Health
- Stephen M. Hewitt
- Laboratory of Pathology, Centers for Cancer Research, National Cancer Institute, National Institutes of Health
- Heike Boisvert
- Ultivue, Inc
- Stephanie Hennek
- Ultivue, Inc
- Mark Bobrow
- Ultivue, Inc
- Md Shakir Uddin Ahmed
- Department of Biology and Center for Cancer Research, Tuskegee University
- Jason White
- Department of Biology and Center for Cancer Research, Tuskegee University
- Clayton Yates
- Department of Biology and Center for Cancer Research, Tuskegee University
- Andrew Aukerman
- Department of Pathology and Cell Biology, Columbia University Irvine Medical Center
- Rami Vanguri
- Department of Pathology and Cell Biology, Columbia University Irvine Medical Center
- Rohan Bareja
- Department Computer Science Department, Columbia University
- Romina Lenci
- Department of Pathology and Cell Biology, Columbia University Irvine Medical Center
- Paula Lucia Farré
- Laboratorio de Oncologıa Molecular y Nuevos Blancos Terapeuticos, Instituto de Biologıa y Medicina Experimental (IBYME), CONICET
- Adriana De Siervi
- Laboratorio de Oncologıa Molecular y Nuevos Blancos Terapeuticos, Instituto de Biologıa y Medicina Experimental (IBYME), CONICET
- Anna María Nápoles
- Division of Intramural Research, National Institutes of Minority Health and Health Disparities, National Institutes of Health
- Nasreen Vohra
- Brody School of Medicine, East Carolina University
- Kevin Gardner
- Department of Pathology and Cell Biology, Columbia University Irvine Medical Center
- DOI
- https://doi.org/10.1038/s42003-021-01651-y
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Through automated image analysis, Singhal et al quantify nuclear versus cytoplasmic distribution of the Kaiso transcription factor in breast cancer patient tissue. They find that Kaiso distribution correlates with breast cancer subtype and overall survival, and discover a link between cytoplasmic Kaiso and autophagy marker LC3.
