Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Basel M. Al-Barghouthi; Larry D. Mesner; Gina M. Calabrese; Daniel Brooks; Steven M. Tommasini; Mary L. Bouxsein; Mark C. Horowitz; Clifford J. Rosen; Kevin Nguyen; Samuel Haddox; Emily A. Farber; Suna Onengut-Gumuscu; Daniel Pomp; Charles R. Farber

doi:10.1038/s41467-021-23649-0

Nature Communications (Jun 2021)

Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Basel M. Al-Barghouthi,
Larry D. Mesner,
Gina M. Calabrese,
Daniel Brooks,
Steven M. Tommasini,
Mary L. Bouxsein,
Mark C. Horowitz,
Clifford J. Rosen,
Kevin Nguyen,
Samuel Haddox,
Emily A. Farber,
Suna Onengut-Gumuscu,
Daniel Pomp,
Charles R. Farber

Affiliations

Basel M. Al-Barghouthi: Center for Public Health Genomics, School of Medicine, University of Virginia
Larry D. Mesner: Center for Public Health Genomics, School of Medicine, University of Virginia
Gina M. Calabrese: Center for Public Health Genomics, School of Medicine, University of Virginia
Daniel Brooks: Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Harvard Medical School
Steven M. Tommasini: Department of Orthopaedics and Rehabilitation, Yale School of Medicine
Mary L. Bouxsein: Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Department of Orthopedic Surgery, Harvard Medical School
Mark C. Horowitz: Department of Orthopaedics and Rehabilitation, Yale School of Medicine
Clifford J. Rosen: Maine Medical Center Research Institute
Kevin Nguyen: Center for Public Health Genomics, School of Medicine, University of Virginia
Samuel Haddox: Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia
Emily A. Farber: Center for Public Health Genomics, School of Medicine, University of Virginia
Suna Onengut-Gumuscu: Center for Public Health Genomics, School of Medicine, University of Virginia
Daniel Pomp: Department of Genetics, University of North Carolina School of Medicine
Charles R. Farber: Center for Public Health Genomics, School of Medicine, University of Virginia

DOI: https://doi.org/10.1038/s41467-021-23649-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying new potential bone strength genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal