Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum (Sep 2014)

Anxiolytic Effect of L-carnitine in Adult Male Rats

  • Zahra Sasaninejad,
  • Maryam Eidi,
  • Reza Ghahramani,
  • Zeinab Ahmarinejad,
  • Ali Rezaei Galeshpol,
  • Fatemeh Rasoulian,
  • Ali Ilchizadeh Kavgani,
  • Marzieh Hajizadeh

Journal volume & issue
Vol. 8, no. 4
pp. 1 – 5

Abstract

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Background and Objectives: The beneficial effect of L-carnitine for treatment of neurological diseases has been investigated in various studies. The aim of the present study was to investigate the effect of L-carnitine supplement on anxiety behavior in adult male rats by elevated plus maze. Methods: In this experimental study, the studied groups were divided into normal, saline, and experimental groups. L-carnitine was administered intraperitoneally at doses of 0.5, 1, 2, and 4 mg/kg were, and saline control group received saline as vehicle. The data were analyzed using one-way ANOVA and Dunnett’s test. The significance level was considered as p<0.05. Results: In this study, the anxiolytic response of the drug was evaluated by elevated plus maze 30 minutes after treatment. L-carnitine treatment increase time spent in open arms, number of entries into open and dark arms or locomotor activity, %OAE, while decreased %OAT (p<0.01). Conclusion: The results of this study indicated that L-carnitine has anxiolytic effect on male rats

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