Anemia in diabetic nephropathy: prevalence, clinical and pathophysiological aspects

Abstract

Aim. To investigate detectability of anemia, its clinical and pathophysiological features in patients with diabetic nephropathy (DN). Material and methods. The trial included 1020 patients with type 1 and 2 diabetes mellitus (DM). DN was diagnosed in 50% of them. Incidence of anemia was compared in 92 DN patients in type 1 DM and in 230 patients with chronic glomerulonephritis (CGN). Concentration of erythropoietin (EP) in blood serum was measured in 94 DN patients in type 1 and 2 DM. Results. Anemia develops in type 1 and 2 DM patients free of DN and unaffected renal filtration function (glomerular filtration rate - GFR > 60 ml/min 1.73 m2) was 23.3 and 18.3%, respectively. In DN patients incidence rate of anemia depended on GFR and increased with growing severity of renal failure reaching 85.7% in GFR

Keywords

• anemia
• diabetes mellitus
• diabetic nephropathy
• chronic glomerulonephritis
• erythropoieti