Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

Bernhard C. Lechtenberg; Marina P. Gehring; Taylor P. Light; Christopher R. Horne; Mike W. Matsumoto; Kalina Hristova; Elena B. Pasquale

doi:10.1038/s41467-021-27343-z

Nature Communications (Dec 2021)

Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

Bernhard C. Lechtenberg,
Marina P. Gehring,
Taylor P. Light,
Christopher R. Horne,
Mike W. Matsumoto,
Kalina Hristova,
Elena B. Pasquale

Affiliations

Bernhard C. Lechtenberg: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Marina P. Gehring: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Taylor P. Light: Department of Materials Science and Engineering, Institute for NanoBioTechnology, Johns Hopkins University
Christopher R. Horne: Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research
Mike W. Matsumoto: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Kalina Hristova: Department of Materials Science and Engineering, Institute for NanoBioTechnology, Johns Hopkins University
Elena B. Pasquale: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute

DOI: https://doi.org/10.1038/s41467-021-27343-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Eph receptor tyrosine kinases and their ephrin ligands mediate cell-cell communication. Here, the authors assess the structure and dynamics of the EphA2 intracellular region and uncover complex effects of phosphorylation within the linker region between EphA2 kinase and SAM domains.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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