EFFICIENCY OF VALVE BRONCHIAL BLOCK WITHIN COMPREHENSIVE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE

Abstract

The objective of the study: to assess efficiency of comprehensive treatment of destructive pulmonary tuberculosis patients with extensive drug resistance using valve bronchial block.Subjects and Methods. Treatment outcomes in 60 patients with destructive pulmonary tuberculosis and extensive drug resistance were analyzed, the age of patients varied from 18 to 60 years old. The main group included 30 patients who had valve bronchial block along with treatment by third line drugs, the comparison group included 30 patients who had the same treatment but with no valve bronchial block. Pneumoperitoneum was used in both groups, should there be indications for it. The significance of difference was defined by χ2 test, the difference was considered significant with p < 0.05.Results of the study. When valve bronchial block was used, positive X-ray changes were observed in 22 (73.3%) patients versus 13 (43.3%) patients in the comparison group (p < 0.05), cavities were healed in 9 (30.0%) patients versus 2 (6.7%) (p < 0.05 with Yates' correction), tuberculosis progressed in 1 (3.3%) patient versus 10 (33.3%) in the comparison group (p < 0.01 with Yates' correction). The bacillary excretion persisted in fewer cases: the one confirmed by smear was persistent in 3 (10.0%) patients from the main group versus 9 (30%) from the comparison group (p > 0.05), and the one confirmed by culture – in 5 (16.8%) patients versus 18 (60.0%) respectively (p > 0.01).

Keywords

• туберкулез
• широкая лекарственная устойчивость мбт
• клапанная бронхоблокация