Neuroendocrinal regulation of bone metabolism in osteoarthritis of large joints (review)

Abstract

The regulation of bone metabolism by adrenergic, cholinergic and endocrine transmitters in osteoarthritis is reviewed. Regulatory effects of α- and β-receptor mechanisms of norepinephrine, M- and N-receptors of acetylcholine, glucocorticosteroids, PTH and peptidergic systems in the bone remodeling process are characterized that can serve as a basis for the development of promising therapies osteoarthritis.

Keywords

• остеоартроз
• нейроэндокринная регуляция
• рецепторы
• osteoarthritis
• neuroendocrinal regulation
• receptors